Name: Anti-Human CD22 (Epratuzumab Biosimilar)
Brand: InnoCyto
SKU: 502602
Price: 650 USD
Availability: InStock

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Anti-Human CD22 (Epratuzumab Biosimilar)

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Cat #	Size	Price
502601	1 mg	$250
502602	5 mg	$650
502603	20 mg	$2000

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Product Details

Clone	Epratuzumab
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Epratuzumab Biosimilar, CD22 Monoclonal Antibody
Isotype	Human IgG1
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human CD22
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Storage Conditions	4ºC
Maximal Shelf Life	12 months
Synonyms	Siglec-2
Target Name	CD22, BL-CAM, Siglec-2
Antibody Type	Recombinant
Research Areas	B cells, Cancer Marker
See All Formats	Clone Epratuzumab

Background Information

Epratuzumab is a humanized monoclonal antibody that belongs to the immunoglobulin G1 kappa (IgG1κ) subclass and is engineered to target CD22, a transmembrane glycoprotein expressed primarily on B lymphocytes. Structurally, Epratuzumab is a recombinant glycoprotein with a molecular mass of approximately 145 to 150 kilodaltons (kDa). The molecule is composed of two identical heavy chains and two identical light chains connected by interchain disulfide bonds, forming the characteristic Y-shaped antibody configuration typical of IgG immunoglobulins. Each heavy chain contains one variable (VH) domain and three constant regions (CH1-CH3), and each light chain comprises one variable (VL) and one constant (CL) domain. The antibody is produced in mammalian expression systems, such as Chinese Hamster Ovary (CHO) cells, ensuring proper glycosylation and folding necessary for biological stability and activity.

The antigen-binding regions of Epratuzumab, located within the complementarity-determining regions (CDRs) of the VH and VL domains, are derived from murine antibody sequences engineered into a human IgG framework to achieve specific recognition of CD22. This epitope binding occurs with high affinity through non-covalent interactions, including hydrogen bonding and van der Waals forces. CD22, a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, functions as an inhibitory coreceptor that modulates B-cell receptor (BCR) signaling. Upon binding to CD22, Epratuzumab influences intracellular signaling dynamics by promoting receptor internalization and partial modulation of downstream pathways involving calcium mobilization and phosphatase recruitment, such as SHP-1 activation in experimental systems.

The Fc (fragment crystallizable) region of Epratuzumab contributes to its stability and pharmacokinetic properties through interactions with neonatal Fc receptors (FcRn), which extend circulating half-life. As an IgG1 molecule, it can also interact with Fc gamma receptors (FcγRs), enabling potential effector functions like limited antibody-dependent cellular cytotoxicity (ADCC) under defined experimental conditions. Overall, Epratuzumab exemplifies a rationally engineered humanized antibody structure optimized for selective targeting of B-cell surface receptors and modulation of immune-signaling pathways in molecular and cellular studies.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

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