Name: Anti-Human CD80 (Galiximab Biosimilar)
Brand: InnoCyto
SKU: 503001
Price: 250 USD
Availability: InStock

Shop Now Contact

Anti-Human CD80 (Galiximab Biosimilar)

InnoCyto Product Image

Cat #	Size	Price
503001	1 mg	$250
503002	5 mg	$750
503003	20 mg	$2000

Bulk/Custom

Product Details

Clone	Galiximab
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Galiximab Biosimilar, CD80 Monoclonal Antibody
Isotype	Human IgG1
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human CD80
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Storage Conditions	4ºC
Maximal Shelf Life	12 months
Synonyms	B7-1
RRID	AB_3739306
Target Name	CD80, B7-1, B7, BB1
Antibody Type	Recombinant
Research Areas	Dendritic cells, Macrophages, B cells, Antigen Presentation, Co-stimulation, Immune Checkpoints
See All Formats	Clone Galiximab

Background Information

Galiximab is a chimeric monoclonal antibody belonging to the immunoglobulin G1 kappa (IgG1κ) subclass, engineered to specifically recognize and bind to the human CD80 antigen, also known as B7-1. Structurally, the molecule is composed of two identical heavy chains and two identical light chains, joined by interchain disulfide bonds in the classical Y-shaped antibody conformation. The molecular weight of Galiximab is approximately 150 kilodaltons (kDa). The antibody is produced using mammalian expression systems that facilitate proper folding, glycosylation, and assembly consistent with human immunoglobulin frameworks.

The variable domains of the heavy (VH) and light (VL) chains, derived from murine sequences, form the antigen-binding regions of Galiximab. These regions contain complementarity-determining regions (CDRs) that determine binding specificity and affinity for CD80. The constant domains are of human origin, providing the molecule with reduced immunogenicity and improved structural stability. The epitope recognized by Galiximab lies on the extracellular domain of CD80, a costimulatory molecule expressed on the surface of activated B cells and antigen-presenting cells. By binding to CD80, Galiximab sterically interferes with its interaction with CD28 and CTLA-4 on T cells. This blockade modulates key costimulatory signals required for full T-cell activation, cytokine production, and proliferation, making it highly relevant for experimental studies in immune signaling and cellular communication.

The Fc (fragment crystallizable) region of Galiximab, consistent with human IgG1 antibodies, contributes to molecular stability and long serum persistence through interaction with the neonatal Fc receptor (FcRn). It also retains the potential to engage Fc gamma receptors (FcγRs), facilitating secondary immune effector activities such as antibody-dependent cellular cytotoxicity (ADCC) in vitro. Overall, Galiximab represents a rationally designed chimeric IgG1κ antibody that integrates murine-derived epitope specificity with human antibody architecture, serving as a model for studying costimulatory receptor–ligand interactions and B-cell–T-cell signaling regulation in immunological research.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

Search Tips