Name: Anti-Human EGFR (Panitumumab Biosimilar)
Brand: InnoCyto
SKU: 504601
Price: 190 USD
Availability: InStock

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Anti-Human EGFR (Panitumumab Biosimilar)

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Cat #	Size	Price
504601	1 mg	$190
504602	5 mg	$590
504603	20 mg	$1390

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Product Details

Clone	Panitumumab
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Panitumumab Biosimilar, Human EGFR/ErbB-1/HER1 Monoclonal Antibody
Isotype	Human IgG2
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human EGFR / ErbB-1 / HER1
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Storage Conditions	4ºC
Maximal Shelf Life	12 months
Synonyms	ErbB1, HER1
RRID	AB_3739322
Target Name	EGFR, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, HER1
Antibody Type	Recombinant
Research Areas	Cancer Marker, Epithelial cells
See All Formats	Clone Panitumumab

Background Information

Panitumumab is a fully human monoclonal antibody of the immunoglobulin G2 kappa (IgG2κ) subclass, specifically engineered to bind with high affinity to the epidermal growth factor receptor (EGFR), also known as ErbB1 or HER1. Structurally, Panitumumab is a recombinant glycoprotein with a molecular weight of approximately 147 kilodaltons (kDa). The molecule comprises two identical heavy chains and two identical light chains interconnected by disulfide bonds, forming the typical Y-shaped structure of immunoglobulin molecules. It is expressed in mammalian cell systems, such as Chinese Hamster Ovary (CHO) cells, allowing proper glycosylation, folding, and assembly consistent with native human antibodies.

The variable domains of Panitumumab’s heavy (VH) and light (VL) chains, which contain complementarity-determining regions (CDRs), mediate specific recognition of EGFR’s extracellular domain III. This region corresponds to the receptor’s ligand-binding site for epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α). By occupying this site, Panitumumab prevents ligand-induced receptor dimerization, autophosphorylation, and subsequent activation of intracellular tyrosine kinase domains. This blockade interferes with downstream signaling cascades such as the RAS-RAF-MEK-ERK and phosphatidylinositol 3-kinase (PI3K)-AKT pathways, which regulate cellular processes including proliferation, differentiation, and survival. In experimental systems, this precise receptor blockade provides a model for studying EGFR-mediated signal regulation and receptor dynamics.

The Fc (fragment crystallizable) domain of Panitumumab, derived from the IgG2 isotype, is characterized by minimal effector activity compared with IgG1 antibodies. It exhibits limited affinity for Fc gamma receptors (FcγRs) and complement component C1q, thereby reducing antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). However, the Fc region contributes to molecular stability and prolongs half-life through interactions with neonatal Fc receptors (FcRn), enabling antibody recycling. Overall, Panitumumab exemplifies a rationally designed human IgG2 monoclonal antibody that combines high-affinity ligand blockade with structural stability, serving as a precise molecular tool for exploring receptor-mediated signaling and protein–protein interactions.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

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