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Anti-Human GP IIb/IIIa (Abciximab Biosimilar)

Cat # Size Price Quantity
5001011 mg$250
5001025 mg$750
50010320 mg$1800

  Bulk/Custom

Product Details

CloneAbciximab
ApplicationFlow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionAbciximab Biosimilar, Glycoprotein IIb/IIIa Receptor Monoclonal Antibody
IsotypeHman IgG1 Fab
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenHuman Glycoprotein IIb/IIIa Receptor
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsGPIIb, GPIIIa
Target NameCD41/CD61
Antibody TypeRecombinant
Research AreasPlatelets, Clotting
See All FormatsClone Abciximab

Background Information

Abciximab is a chimeric monoclonal antibody fragment developed to selectively bind and inhibit specific integrin receptors on platelet surfaces. Structurally, it is the Fab (antigen-binding) fragment of the monoclonal antibody 7E3, designed using recombinant DNA technology. This antibody originates from a murine (mouse) immunoglobulin engineered to contain both murine variable regions and human constant regions, resulting in a chimeric composition that combines high specificity with structural compatibility to human proteins. The molecule has a molecular mass of approximately 47.6 kilodaltons (kDa) and maintains the typical immunoglobulin Fab architecture, comprising one complete light chain and the variable and first constant domains of the heavy chain, connected via disulfide bonds.

Functionally, Abciximab exerts its activity through high-affinity binding to the glycoprotein (GP) IIb/IIIa receptor complex, also known as integrin αIIbβ3, on platelets. This receptor plays a crucial role in mediating platelet aggregation by serving as the final common pathway for fibrinogen, von Willebrand factor, and other adhesive ligand binding. By occupying the ligand-binding sites of this integrin complex, Abciximab sterically hinders the interaction between platelets and adhesive molecules, effectively inhibiting crosslinking and aggregation processes. In addition to the αIIbβ3 receptor, Abciximab also displays binding affinity toward related integrins such as αvβ3 and Mac-1 (CD11b/CD18), contributing to its ability to modulate a wider range of cell adhesion phenomena in research contexts.

At the molecular level, Abciximab's binding is non-competitive and characterized by slow dissociation kinetics, allowing the molecule to remain attached to its receptor targets for extended periods. The interaction occurs mainly through complementarity-determining regions (CDRs) located in the antibody’s variable domains, which recognize specific conformational epitopes on the integrin surface. Through these mechanisms, Abciximab provides a precise biochemical model for investigating integrin-mediated signaling, receptor-ligand dynamics, and the molecular regulation of platelet adhesion and aggregation.

Data Sheets

Anti-Human GP IIb/IIIa (Abciximab Biosimilar) TDS

Related Protocols

Flow Cytometry Protocol

Related Products

PE Anti-Mouse/Human CD11b (Integrin αM) Antibody, Clone M1/70

Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.