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Anti-Human RSV (Palivizumab Biosimilar)

Cat # Size Price Quantity
5045011 mg$190
5045025 mg$590
50450320 mg$1390

  Bulk/Custom

Product Details

ClonePalivizumab
ApplicationFlow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionPalivizumab Biosimilar, RSV Monoclonal Antibody
IsotypeHuman IgG1
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenRespiratory Syncytial Virus F protein
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsF protein
RRIDAB_3739321
Target NameRSV, Respiratory Syncytial Virus
Antibody TypeRecombinant
Research AreasInfectious Diseases, RSV
See All FormatsClone Palivizumab

Background Information

Palivizumab is a humanized monoclonal antibody belonging to the immunoglobulin G1 kappa (IgG1κ) subclass, developed to specifically target the fusion (F) glycoprotein of the respiratory syncytial virus (RSV). Structurally, Palivizumab is a glycoprotein with a molecular weight of approximately 148 kilodaltons (kDa). It is composed of two identical heavy chains and two identical light chains linked by disulfide bonds, forming the canonical Y-shaped IgG structure. The antibody is produced in mammalian expression systems, such as Chinese Hamster Ovary (CHO) cells, which ensure proper glycosylation, folding, and assembly consistent with human immunoglobulins.

The variable domains of Palivizumab’s heavy (VH) and light (VL) chains contain complementarity-determining regions (CDRs) responsible for antigen specificity. These CDRs were derived from murine antibody sequences through humanization to minimize non-human components while retaining high-affinity binding. The antibody recognizes a conserved epitope within the A antigenic site of the RSV F protein, a structurally important domain responsible for mediating viral fusion with host cell membranes. By binding to this epitope on the prefusion and postfusion forms of the F protein, Palivizumab sterically impedes conformational rearrangements required for membrane fusion, thereby preventing viral entry and subsequent cell-to-cell spread in model systems.

The Fc (fragment crystallizable) domain of Palivizumab, derived from the human IgG1 isotype, confers structural stability and extends circulatory half-life by engaging the neonatal Fc receptor (FcRn), which recycles the antibody and protects it from lysosomal degradation. While the Fc region is capable of interacting with Fc gamma receptors (FcγRs) and complement component C1q, Palivizumab’s primary function is neutralization rather than immune effector activation. Overall, Palivizumab exemplifies precise monoclonal antibody engineering that combines high-affinity viral protein recognition with a stable human IgG1 scaffold, serving as a model for studying viral fusion inhibition and protein–antibody interactions in molecular virology research.

Data Sheets

Anti-Human RSV (Palivizumab Biosimilar) TDS

Related Protocols

Flow Cytometry Protocol

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Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.