Name: Anti-Human VEGF (Fab) (Ranibizumab Biosimilar)
Brand: InnoCyto
SKU: 505101
Price: 500 USD
Availability: InStock

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Anti-Human VEGF (Fab) (Ranibizumab Biosimilar)

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Cat #	Size	Price	Quantity
505101	2 mg	$500
505102	10 mg	$1250

Bulk/Custom

Product Details

Clone	Ranibizumab
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Anti-Human VEGF (Fab) (Ranibizumab Biosimilar)
Isotype	Human IgG1
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human VEGF
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Storage Conditions	4ºC
Maximal Shelf Life	12 months
Synonyms	VEGF-A
RRID	AB_3739327
Target Name	Vascular endothelial growth factor, VEGF-A, VEGFA, VEGF
Antibody Type	Recombinant
Research Areas	Cytokines, Angiogenesis, Hypoxia
See All Formats	Clone Ranibizumab

Background Information

Ranibizumab is a recombinant humanized monoclonal antibody fragment (Fab) designed to specifically bind and neutralize vascular endothelial growth factor A (VEGF-A). Structurally, it is a single antigen-binding fragment derived from the same parent murine antibody as bevacizumab but lacks the Fc (fragment crystallizable) region, which distinguishes it from full-length immunoglobulin G (IgG) antibodies. The absence of the Fc domain results in a smaller, monovalent molecule with a molecular weight of approximately 48 kilodaltons (kDa).

The molecular structure of Ranibizumab comprises a variable heavy (VH) domain and a variable light (VL) domain connected to their respective constant regions (CH1 and CL). Together, these domains form a single high-affinity antigen-binding site, with complementarity-determining regions (CDRs) mediating specific binding to VEGF-A isoforms, including VEGF121, VEGF165, and VEGF189. The CDRs establish strong non-covalent interactions with residues located within the heparin-binding domain of VEGF-A. This high-affinity binding occurs in the picomolar range, effectively sequestering VEGF-A and preventing it from binding to its cell surface receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR). The disruption of VEGF-receptor interactions inhibits downstream receptor dimerization and phosphorylation, blocking intracellular signaling pathways such as MAPK and PI3K-AKT that mediate vascular permeability, endothelial proliferation, and angiogenesis in experimental systems.

Functionally, Ranibizumab’s small molecular size enhances tissue penetration and allows rapid diffusion through extracellular matrices, making it suitable for localized VEGF inhibition at target sites. Although it lacks the Fc fragment, and thus cannot engage Fc gamma receptors (FcγRs) or activate complement, it retains high structural stability and solubility due to optimized domain folding and disulfide bridge formation. Overall, Ranibizumab exemplifies precision antibody engineering, combining molecular compactness and epitope specificity to investigate VEGF-mediated signaling and angiogenic processes in molecular biology research.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

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