Name: Anti-Human VEGFR-2 (Ramucirumab Biosimilar)
Brand: InnoCyto
SKU: 505001
Price: 190 USD
Availability: InStock

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Anti-Human VEGFR-2 (Ramucirumab Biosimilar)

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Cat #	Size	Price
505001	1 mg	$190
505002	5 mg	$590
505003	20 mg	$1390

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Product Details

Clone	Ramucirumab
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Anti-Human VEGFR-2 (Ramucirumab Biosimilar)
Isotype	Human IgG1
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human VEGFR2
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Storage Conditions	4ºC
Maximal Shelf Life	12 months
RRID	AB_3739326
Target Name	VEGFR2, VEGF-R2, KDR, Tyrosin kinase growth factor receptor, homolog of FLK1 (FLK1), VEGFR
Antibody Type	Recombinant
Research Areas	Endothelial cells, Angiogenesis, Inflammation, Hematopoietic Stem cells, Cancer Marker
See All Formats	Clone Ramucirumab

Background Information

Ramucirumab is a fully human monoclonal antibody that belongs to the immunoglobulin G1 (IgG1) subclass and is engineered to bind with high specificity to vascular endothelial growth factor receptor 2 (VEGFR-2), also known as kinase insert domain receptor (KDR). Structurally, Ramucirumab is a glycoprotein with an approximate molecular weight of 147 kilodaltons (kDa). The molecule consists of two identical heavy chains and two identical light chains interconnected by disulfide bonds, forming the canonical Y-shaped antibody configuration typical of IgG molecules. It is produced using recombinant DNA technology in mammalian expression systems such as Chinese Hamster Ovary (CHO) cells to ensure proper folding, disulfide linkage formation, and glycosylation compatible with human proteins.

The variable regions (VH and VL) of Ramucirumab define its antigen-binding site, composed of complementarity-determining regions (CDRs) that mediate specific, high-affinity recognition of the extracellular domain of VEGFR-2. This region corresponds to the receptor’s ligand-binding site for vascular endothelial growth factor A (VEGF-A), VEGF-C, and VEGF-D. By binding to this epitope, Ramucirumab sterically blocks the interaction between VEGFR-2 and its ligands, preventing receptor dimerization and autophosphorylation events required for downstream signaling activation. This inhibition disrupts intracellular pathways, primarily the MAPK (mitogen-activated protein kinase) and PI3K-AKT cascades, that regulate endothelial cell proliferation, migration, and survival in experimental systems investigating angiogenic control.

The Fc (fragment crystallizable) region of Ramucirumab is derived from human IgG1, providing structural stability and an extended half-life through neonatal Fc receptor (FcRn)–mediated recycling. It also permits limited engagement with Fc gamma receptors (FcγRs), enabling potential antibody-dependent cellular cytotoxicity (ADCC) under certain conditions, though this is not the primary mechanism. Overall, Ramucirumab exemplifies rational antibody design, combining precise receptor targeting, stable IgG architecture, and defined signaling blockade, to model ligand–receptor regulation and angiogenic signaling mechanisms at the molecular level.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

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