APC Anti-mouse CD19 Antibody

Cat #	Size	Price	Quantity
201909	25 tests	$80
201910	100 tests	$220

Bulk/Custom

Product Details

Clone	1D3
Application	Flow Cytometry
Reactivity	Mouse
Format	APC
Target Name	CD19, B4, CVID3, Leu-12, MGC12802
Isotype	Rat IgG2a
Antibody Type	Monoclonal
Regulatory Status	RUO
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA
Protein Concentration	Supplied at a lot-specific concentration.
Storage&Handling	The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Recommended Usage	For flow cytometric staining, it is recommended to use 5 uL of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application.
Excitation Laser	Red Laser (633 nm)
Research Areas	B cells, Plasma cells, Cancer Marker, follicular Dendritic cells
See All Formats	Clone 1D3

Background Information

CD19, also known as B-lymphocyte antigen CD19, B4, Leu-12, or CVID3, is a type I transmembrane glycoprotein encoded by the CD19 gene. It is expressed throughout B cell development from the pro-B stage to mature B cells and is present on most B lineage cells. CD19 functions as an adaptor protein, recruiting cytoplasmic signaling molecules to the membrane, and forms part of the CD19/CD21/CD81 complex, which lowers the activation threshold for B cell receptor (BCR) signaling. Because of its consistent expression on B cells, CD19 serves as a key biomarker for B cell development and is widely used in the diagnosis of B cell lymphomas and leukemias. It is also a major therapeutic target in immunotherapies, including CAR T-cell therapy for B cell malignancies.

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