Name: In Vivo Star Anti-Human CD56 (NCAM) Antibody
Brand: InnoCyto
SKU: 516903
Price: 1100 USD
Availability: InStock

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In Vivo Star Anti-Human CD56 (NCAM) Antibody

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Cat #	Size	Price
516901	1 mg	$160
516902	5 mg	$400
516903	25 mg	$1100

Bulk/Custom

Product Details

Clone	N901
Application	Direct ELISA, functional assay, Flow Cytometry
Host Species	CHO cells
Reactivity	Human
Format	Liquid
Target Name	CD56, Leu-19, NKH1
Product Description	In vivo Grade Recombinant Anti-human CD56 Monoclonal Antibody
Isotype	Mouse IgG1 Kappa
Antibody Type	Recombinant
Regulatory Status	RUO
Purity	>95% by reducing SDS-PAGE
Endotoxin	< 1 EU per 1 mg of the protein by the LAL method.
Storage Conditions	4ºC
Grade	In vivo
Recommended Usage	This product is suitable in in vitro functional assays or in vivo on human cells used in animal models. Optimal amounts need to be determined empirically for each experiment.
Research Areas	NK cells, NKT cells, Adhesion Molecules, Neurons, Cancer Marker
See All Formats	Clone N901

Background Information

CD56, also known as neural cell adhesion molecule (NCAM), is a multifunctional cell surface glycoprotein belonging to the immunoglobulin (Ig) superfamily. While originally characterized in the nervous system, CD56 is best known in immunology as a defining marker of natural killer (NK) cells and a subset of T lymphocytes. Its expression level on NK cells is used to distinguish functionally distinct subsets, most notably CD56bright and CD56dim NK cells.

Structurally, CD56 is a type I transmembrane protein composed of five extracellular Ig-like domains and two fibronectin type III domains, followed by a single transmembrane region and a cytoplasmic tail. Alternative splicing generates several isoforms (primarily NCAM-120, NCAM-140, and NCAM-180), which differ in their cytoplasmic domains and signaling capabilities. CD56 can also be post-translationally modified by polysialylation, a feature that modulates its adhesive properties and is particularly important in neural development.

Functionally, CD56 mediates homophilic interactions (CD56-CD56 binding) as well as heterophilic interactions with other ligands, including heparan sulfate proteoglycans, fibroblast growth factor receptor (FGFR), and components of the extracellular matrix. In the immune system, CD56 plays a role in cell-cell adhesion, immune synapse formation, and signal transduction. CD56bright NK cells are typically less cytotoxic but produce high levels of cytokines such as IFN-γ, contributing to immune regulation, whereas CD56dim NK cells exhibit potent cytotoxic activity against virally infected and transformed cells.

CD56 is implicated in several diseases. Aberrant or ectopic expression of CD56 is observed in various malignancies, including multiple myeloma, small cell lung carcinoma, neuroendocrine tumors, and certain leukemias and lymphomas. In hematologic diagnostics, CD56 expression is routinely used as an immunophenotypic marker to aid in disease classification and prognosis. For example, CD56 expression in multiple myeloma has been associated with altered patterns of bone marrow adhesion and disease behavior.

Therapeutically, CD56 has emerged as a potential target in oncology. Antibody-based approaches and antibody–drug conjugates directed against CD56 have been explored to selectively eliminate CD56-expressing tumor cells, particularly in neuroendocrine cancers and hematologic malignancies. In addition, CD56 is widely used as a marker for NK cell isolation, monitoring, and quality control in NK cell–based immunotherapies, underscoring its importance in both basic research and clinical applications.

Frequently Asked Questions

What are In Vivo Star Biofunctional Antibodies?

In Vivo Star antibodies are premium-grade monoclonal antibodies purified and formulated specifically for use in animal studies. Each lot is manufactured under stringent quality controls to ensure the low endotoxin levels, high purity, and functional activity required for reliable in vivo results.

How are these antibodies different from standard research antibodies (e.g., for Western blot or flow cytometry)?

Standard research antibodies are optimized for in vitro detection assays and may contain preservatives, carrier proteins (like BSA), or higher endotoxin levels unsuitable for injection. In Vivo Star antibodies are formulated in injectable-grade, azide-free, low-endotoxin buffers and validated for functional bioactivity in living systems rather than just antigen binding.

What endotoxin and purity specifications do these antibodies meet?

All In Vivo Star antibodies are tested and certified to meet low-endotoxin thresholds (typically <1 EU/mg, lot-dependent) using the LAL (Limulus Amebocyte Lysate) assay, and are purified to ≥95% purity by SEC-HPLC or SDS-PAGE. Exact specifications are provided on the Certificate of Analysis (CoA) for each lot.

Are these antibodies azide-free and carrier-free?

All In Vivo Star antibodies are formulated without sodium azide and without carrier proteins such as BSA or gelatin, since both can interfere with animal physiology or immune readouts during in vivo studies.

Do you provide isotype controls?

Matched isotype control antibodies (same host species, isotype, and formulation) are available upon request for most clones to support proper experimental controls.

How should In Vivo Star antibodies be stored and handled?

Store at 4°C for short-term use and avoid repeated freeze-thaw cycles, which can reduce bioactivity; aliquoting is recommended for long-term storage per the product-specific storage instructions on the Certificate of Analysis. Always confirm storage conditions and expiration on the CoA that accompanies each lot, as these can vary slightly by antibody.

Have a product or application question? Consult our FAQs or contact us.

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