Shop Now Contact

Anti-Human HER2 (Pertuzumab Biosimilar)

Cat # Size Price Quantity
5048011 mg$190
5048025 mg$590
50480320 mg$1800

  Bulk/Custom

Product Details

ClonePertuzumab
ApplicationFlow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionAnti-Human HER2 (Pertuzumab Biosimilar)
IsotypeHuman IgG1
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenHuman ErbB-2 / Her2
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsErbB2
RRIDAB_3739324
Target NameHER2, HER-2, ERBB2, CD340, neu, MLN19, NEU, NGL, TKR1
Antibody TypeRecombinant
Research AreasMesenchymal Stem Cells, Embryogenesis, Cancer Marker, Cancer Immunology
See All FormatsClone Pertuzumab

Background Information

Pertuzumab is a recombinant humanized monoclonal antibody of the immunoglobulin G1 kappa (IgG1κ) subclass, engineered to specifically target the extracellular domain II (also known as the dimerization domain) of the human epidermal growth factor receptor 2 (HER2, or ErbB2). Structurally, Pertuzumab is a glycoprotein with a molecular mass of approximately 148 kilodaltons (kDa). The molecule is composed of two identical heavy chains and two identical light chains, linked by interchain disulfide bonds to form the characteristic Y-shaped structure typical of IgG antibodies. It is produced in mammalian cell expression systems such as Chinese Hamster Ovary (CHO) cells, which enable proper folding, glycosylation, and molecular stability.

The variable regions of Pertuzumab’s heavy (VH) and light (VL) chains contain complementarity-determining regions (CDRs) that determine the antibody’s high specificity and affinity for the domain II region of HER2. This domain is critical for receptor dimerization with other members of the ErbB family, such as HER3 and EGFR (HER1). By binding to this domain, Pertuzumab sterically hinders the heterodimerization process that normally activates HER2-mediated intracellular signaling pathways. These pathways include the RAS-RAF-MEK-ERK and PI3K-AKT cascades, which regulate gene expression, cellular growth, and survival in experimental systems. In doing so, Pertuzumab acts at the molecular level to disrupt ligand-dependent receptor crosstalk and downstream phosphorylation cascades.

The Fc (fragment crystallizable) region of Pertuzumab, derived from human IgG1, contributes to structural integrity, pharmacokinetic stability, and interaction with the neonatal Fc receptor (FcRn), allowing antibody recycling and prolonged circulatory half-life. Additionally, the Fc region can engage Fc gamma receptors (FcγRs), enabling effector mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) in vitro.

Data Sheets

Anti-Human HER2 (Pertuzumab Biosimilar) TDS

Related Protocols

Flow Cytometry Protocol

Related Products

Human HER2 (CD340) Protein (C-His-Avi)

Biotin Human HER2 (CD340) Protein (C-His-Avi)

Human HER2 (CD340) Protein (C-His)

Anti-Human HER2 (Trastuzumab Biosimilar), Clone Trastuzumab

Anti-Human HER2 (Trastuzumab Biosimilar), Clone Trastuzumab

PE Human HER2 (CD340) Protein (C-His)

Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.