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Anti-Human LAG-3 (Relatlimab Biosimilar)

Cat # Size Price Quantity
5052011 mg$175
5052025 mg$590
50520320 mg$1800

  Bulk/Custom

Product Details

CloneRelatlimab
ApplicationFlow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionAnti-Human LAG-3 (Relatlimab Biosimilar)
IsotypeHuman IgG4
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenHuman LAG-3
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsCD223
RRIDAB_3739328
Target NameCD223, LAG3, LAG-3, lymphocyte-activation gene-3
Antibody TypeRecombinant
Research AreasT cells, Tregs, Activated NK cells, Immune Checkpoints, Exhaustion
See All FormatsClone Relatlimab

Background Information

Relatlimab is a fully human monoclonal antibody belonging to the immunoglobulin G4 (IgG4) subclass, engineered to specifically target lymphocyte activation gene-3 (LAG-3, also known as CD223), a surface receptor involved in the regulation of T-cell activity. Structurally, Relatlimab is composed of two identical heavy chains and two identical light chains connected by interchain disulfide bonds, forming the canonical Y-shaped configuration typical of IgG molecules. The antibody has an approximate molecular weight of 146 kilodaltons (kDa) and is produced in mammalian expression systems, such as Chinese Hamster Ovary (CHO) cells, ensuring correct folding, assembly, and human-like glycosylation.

The antigen-binding regions of Relatlimab are formed by the complementarity-determining regions (CDRs) within the variable (VH and VL) domains of each chain. These CDR loops mediate high-affinity, selective recognition of an epitope on the extracellular immunoglobulin-like domains of LAG-3. The interaction is stabilized through hydrogen bonding, electrostatic complementarity, and hydrophobic contacts, yielding sub-nanomolar binding affinities. LAG-3 functions as an inhibitory immune checkpoint receptor that modulates T-cell proliferation and activation by binding to its natural ligand, major histocompatibility complex class II (MHC-II), and additional ligands such as fibrinogen-like protein 1 (FGL1). By engaging the receptor’s extracellular domain, Relatlimab sterically blocks the LAG-3–ligand interaction. This disruption prevents transmission of inhibitory signals that downregulate T-cell receptor (TCR) signaling pathways, restoring or prolonging T-cell effector activity in immune-regulation model systems.

The Fc (fragment crystallizable) portion of Relatlimab contains an IgG4 backbone with a stabilizing serine-to-proline mutation (S228P) in the hinge region to prevent half-antibody formation. The IgG4 isotype minimizes effector functions such as complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) while preserving structural stability and extended half-life through neonatal Fc receptor (FcRn) recycling.

Data Sheets

Anti-Human LAG-3 (Relatlimab Biosimilar) TDS

Related Protocols

Flow Cytometry Protocol

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Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

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