Shop Now Contact

Anti-Human VEGF-A (Brolucizumab Biosimilar)

Cat # Size Price Quantity
5011011 mg$500
5011025 mg$1200
50110320 mg$3900

  Bulk/Custom

Product Details

CloneBrolucizumab
ApplicationNeutralization, Intracellular Flow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionAnti-Human VEGF-A (Brolucizumab Biosimilar)
IsotypeHuman IgG1
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenHuman VEGF-A
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Min Sample Size1 mg
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsVEGF
Target NameVEGF-A
Research AreasCytokines, Angiogenesis, Hypoxia
See All FormatsClone Brolucizumab

Background Information

Brolucizumab is a humanized single-chain antibody fragment (scFv) engineered to bind vascular endothelial growth factor A (VEGF-A) with high specificity and affinity. Structurally, it differs from conventional full-length antibodies in that it consists of only the variable regions of the heavy (VH) and light (VL) chains connected by a flexible peptide linker, forming a single polypeptide chain rather than a whole immunoglobulin molecule. The absence of constant (Fc) regions significantly reduces its molecular mass, approximately 26 kilodaltons (kDa), making Brolucizumab one of the smallest antibody-derived therapeutic proteins developed for VEGF inhibition.

The functional activity of Brolucizumab centers on its ability to bind with high affinity to all major isoforms of VEGF-A, including VEGF121, VEGF165, and VEGF189. Through its antigen-binding site, formed by complementarity-determining regions (CDRs) within the VH and VL domains, Brolucizumab effectively neutralizes VEGF-A, preventing its interaction with surface receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR) on endothelial cells. Blocking this ligand–receptor interaction inhibits receptor dimerization and downstream signaling cascades, including those mediated by the MAPK and PI3K-AKT pathways, which are involved in endothelial cell proliferation, migration, and vascular permeability.

Structurally optimized for stability and solubility, Brolucizumab maintains a monomeric form under physiological conditions and exhibits strong biophysical integrity despite lacking glycosylation. The small molecular size facilitates efficient tissue penetration and high molar binding capacity per administered volume. Overall, Brolucizumab exemplifies a rationally designed antibody fragment, combining the precise antigen recognition of conventional antibodies with the compactness and pharmacokinetic advantages of a streamlined single-chain variable fragment architecture.

Data Sheets

Anti-Human VEGF-A (Brolucizumab Biosimilar) TDS

Related Products

Anti-Human VEGF (Aflibercept Biosimilar), Clone Aflibercept

Anti-Human VEGF (Bevacizumab Biosimilar), Clone Bevacizumab

Anti-Human VEGF (Fab) (Ranibizumab Biosimilar), Clone Ranibizumab

In Vivo Star Anti-Mouse VEGF Antibody, Clone B20-4.1.1

In Vivo Star Anti-Mouse CD279 (PD1) / VEGF-A Bispecific Antibody, Clone RMP1-14 / B20-4.1.1

In Vivo Star Anti-Mouse CD274 (PD-L1) / VEGF-A Bispecific Antibody, Clone 10F.9G2 / B20-4.1.1

Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.