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Anti-Human VEGF (Bevacizumab Biosimilar)

Cat # Size Price Quantity
5009011 mg$125
5009025 mg$400
50090320 mg$960

  Bulk/Custom

Product Details

CloneBevacizumab
ApplicationNeutralization, Intracellular Flow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionBevacizumab Biosimilar, Human VEGF Monoclonal Antibody
IsotypeHuman IgG1
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenHuman VEGF
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Min Sample Size1 mg
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsVEGF-A
Target NameVEGF
Research AreasCytokines, Angiogenesis, Hypoxia
See All FormatsClone Bevacizumab

Background Information

Bevacizumab is a recombinant humanized monoclonal antibody belonging to the immunoglobulin G1 (IgG1) subclass. It is designed to specifically bind to vascular endothelial growth factor A (VEGF-A), a critical signaling glycoprotein that regulates angiogenesis and vascular permeability. Structurally, Bevacizumab is composed of two identical heavy chains and two identical light chains, each linked by disulfide bonds to form a Y-shaped configuration typical of IgG antibodies, with a total molecular weight of approximately 149 kilodaltons (kDa).

The variable regions contain three complementarity-determining regions (CDRs) within each chain, forming the paratope that interacts with specific epitopes on human VEGF-A. This binding is mediated through hydrogen bonding, van der Waals forces, and electrostatic interactions that confer Bevacizumab high affinity and specificity, typically in the nanomolar range. The antigen-binding process is highly selective, preventing VEGF-A from engaging its native receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR), located on the surface of endothelial cells. This molecular blockade inhibits receptor dimerization and downstream intracellular signaling cascades, including the MAPK and PI3K-AKT pathways, which are responsible for cellular proliferation, migration, and survival.

The constant (Fc) region of Bevacizumab contributes structural stability and extends the molecule’s circulating half-life through neonatal Fc receptor (FcRn) recycling. It also allows the antibody to maintain dimeric stability under physiological conditions. Bevacizumab’s glycosylation pattern within its Fc domain supports folding and solubility while minimizing undesired immune effector function such as complement activation or antibody-dependent cytotoxicity.

Data Sheets

Anti-Human VEGF (Bevacizumab Biosimilar) TDS

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Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.