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Anti-RSV (Felvizumab Biosimilar)

Cat # Size Price Quantity
5029011 mg$250
5029025 mg$750
50290320 mg$2000

  Bulk/Custom

Product Details

CloneFelvizumab
ApplicationFlow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityRSV
FormatLiquid
Product DescriptionFelvizumab Biosimilar, RSV Monoclonal Antibody
IsotypeHuman IgG1
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenRSV
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsF protein
Target NameRSV, Respiratory Syncytial Virus
Antibody TypeRecombinant
Research AreasInfectious Diseases, RSV
See All FormatsClone Felvizumab

Background Information

Felvizumab, also known as RSHZ19, is a humanized monoclonal antibody that belongs to the immunoglobulin G1 kappa (IgG1κ) subclass. It was engineered to target a highly conserved epitope on the fusion (F) glycoprotein of the respiratory syncytial virus (RSV), specifically binding to amino acid residues 417–432 within the F protein. Structurally, Felvizumab is composed of two identical heavy chains and two identical light chains linked by interchain disulfide bonds, forming the typical Y-shaped conformation of IgG antibodies. The molecule has an approximate molecular weight of 150 kilodaltons (kDa) and is produced using mammalian expression systems such as Chinese Hamster Ovary (CHO) cells to ensure proper folding and glycosylation.

The variable domains of Felvizumab’s heavy (VH) and light (VL) chains contain complementarity-determining regions (CDRs) derived from murine antibody sequences. These CDRs form the paratope, which interacts with high specificity and affinity to a linear epitope within the F protein of RSV. This binding site was selected for its conservation and structural importance in mediating the conformational changes required for viral fusion with host cell membranes. By engaging this epitope, Felvizumab stabilizes the prefusion conformation of the F protein or sterically hinders its rearrangement into the postfusion form, thereby preventing membrane fusion and viral entry in experimental systems modeling virus–cell interactions.


The Fc (fragment crystallizable) region of Felvizumab is fully human and confers structural stability and extended serum half-life through interaction with the neonatal Fc receptor (FcRn). It also has potential effector capabilities through binding to Fc gamma receptors (FcγRs), which can mediate secondary immune mechanisms in vitro. Overall, Felvizumab exemplifies rational antibody engineering integrating murine-derived antigen specificity with human immunoglobulin scaffolding, optimized for strong target recognition and inhibition of viral fusion processes in virological and structural biology research.

Data Sheets

Anti-RSV (Felvizumab Biosimilar) TDS

Related Protocols

Flow Cytometry Protocol

Related Products

Anti-Human RSV (Palivizumab Biosimilar), Clone Palivizumab

Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.