Name: Anti-Human PD-L1 (Atezolizumab Biosimilar)
Brand: InnoCyto
SKU: 500602
Price: 590 USD
Availability: InStock

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Anti-Human PD-L1 (Atezolizumab Biosimilar)

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Cat #	Size	Price
500601	1 mg	$190
500602	5 mg	$590
500603	20 mg	$1390

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Product Details

Clone	Atezolizuma
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Atezolizumab Biosimilar, Endotoxin 0.05 EU/mg
Isotype	Human IgG1
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human PD-L1
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Min Sample Size	1 mg
Storage Conditions	4ºC
Maximal Shelf Life	12 months
Synonyms	CD274, B7-H1
Target Name	PD-L1, PDL1 CD274, B7-H1
Antibody Type	Recombinant
Research Areas	Activated T cells, Activated B cells, Monocytes, Macrophages, Dendritic cells, NK cells, Immune Checkpoints, Cancer Immunology
See All Formats	Clone Atezolizuma

Background Information

Atezolizumab is a fully humanized monoclonal antibody designed to specifically target and bind to the programmed death-ligand 1 (PD-L1) molecule. Structurally, it belongs to the immunoglobulin G1 (IgG1) subclass and has a molecular weight of approximately 145 kilodaltons (kDa). The molecule consists of two identical heavy chains and two identical light chains, each containing variable (V) and constant (C) domains, joined by disulfide bonds to form the classical Y-shaped antibody structure.

The variable regions of Atezolizumab’s Fab fragments contain highly specific complementarity-determining regions (CDRs) that recognize and bind to human PD-L1. This binding interface involves both hydrogen bonding and hydrophobic interactions that confer high affinity and selectivity. By engaging PD-L1, Atezolizumab prevents it from interacting with its receptors, programmed death-1 (PD-1) and B7.1 (CD80), on T cells and other immune cells. The inhibition of these ligand-receptor interactions disrupts key inhibitory signaling cascades that normally attenuate T-cell activation, thereby restoring or sustaining the functional activity of immune effector cells in experimental systems.

Importantly, the Fc region of Atezolizumab has been selectively engineered to eliminate antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). This is achieved through specific amino acid substitutions in the Fc domain that reduce binding to Fc gamma receptors (FcγRs) and complement component C1q. These modifications allow Atezolizumab to block PD-L1 function without depleting cells that express the molecule. Biophysically, the molecule demonstrates high solubility and stability, with a long serum half-life maintained through neonatal Fc receptor (FcRn) recycling. In sum, Atezolizumab exemplifies a rationally engineered IgG1 framework optimized for precise ligand blockade and controlled immune signaling modulation.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

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