Name: Anti-Human PD-L1 (Avelumab Biosimilar)
Brand: InnoCyto
SKU: 500702
Price: 750 USD
Availability: InStock

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Anti-Human PD-L1 (Avelumab Biosimilar)

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Cat #	Size	Price
500701	1 mg	$190
500702	5 mg	$750
500703	20 mg	$1800

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Product Details

Clone	Avelumab
Application	Flow cytometry, animal model study
Host Species	Mammalian cells
Reactivity	Human
Format	Liquid
Product Description	Anti-Human PD-L1 (Avelumab Biosimilar)
Isotype	Human IgG1
Regulatory Status	RUO
Clonality	Recombinant
Immunogen	Human PD-L1
Species specificity	Human
Purity	>95% by reducing SDS-PAGE
Grade	In vivo
Storage Conditions	4ºC
Maximal Shelf Life	12 months
Synonyms	CD274, B7-H1
Target Name	PD-L1, PDL1 CD274, B7-H1
Antibody Type	Recombinant
Research Areas	Activated T cells, Activated B cells, Monocytes, Macrophages, Dendritic cells, NK cells, Immune Checkpoints, Cancer Immunology
See All Formats	Clone Avelumab

Background Information

Avelumab is a fully human monoclonal antibody classified as an immunoglobulin G1 lambda (IgG1λ) isotype. It is produced through recombinant DNA technology using mammalian expression systems, typically Chinese Hamster Ovary (CHO) cells, which ensure proper post-translational folding, glycosylation, and disulfide bond formation. The molecule has an approximate molecular weight of 147 kilodaltons (kDa) and displays the standard Y-shaped antibody structure composed of two identical heavy chains and two identical light chains joined by disulfide linkages. Each heavy chain contains one variable and three constant domains, while each light chain comprises one variable and one constant domain. Together, these domains form two antigen-binding fragments (Fab) and a single crystallizable fragment (Fc) responsible for effector interactions.

Structurally, Avelumab’s antigen-binding regions, specifically its complementarity-determining regions (CDRs) located within the variable domains, confer high specificity toward programmed death-ligand 1 (PD-L1). By binding to PD-L1, the antibody prevents its interaction with programmed death-1 (PD-1) and B7.1 (CD80) receptors on T cells and antigen-presenting cells. This blockade interrupts inhibitory immune signaling and restores the potential for immune cell activation in experimental systems investigating immune checkpoint regulation. Avelumab binds PD-L1 through a high-affinity interaction characterized by extensive hydrogen bonding and shape complementarity, typically reflected by equilibrium dissociation constants in the low-nanomolar range.

Unlike certain other antibodies targeting the same pathway, Avelumab retains an unmodified Fc region, allowing it to mediate immune effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) under suitable assay conditions. The Fc portion also interacts with neonatal Fc receptors (FcRn) to promote recycling and extend the antibody’s half-life in circulation. Overall, Avelumab exemplifies a rationally engineered IgG1 monoclonal antibody, with a structural design optimized for precise antigen recognition, functional stability, and the capacity to engage immune effector mechanisms during molecular and cellular investigations.

Frequently Asked Questions

What are InnoCyto Biosimilar products?

InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.

How similar are these biosimilars to the original therapeutic antibody?

Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.

Are these antibodies suitable for in vivo studies?

Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.

What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?

A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.

What quality and purity standards do biosimilar antibodies meet?

All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.

Which therapeutic targets and mechanisms are covered in the Biosimilar line?

The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.

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