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Anti-Human PD-L1 (Durvalumab Biosimilar)

Cat # Size Price Quantity
5022011 mg$190
5022025 mg$590
50220320 mg$1390

  Bulk/Custom

Product Details

CloneDurvalumab
ApplicationFlow cytometry, animal model study
Host SpeciesMammalian cells
ReactivityHuman
FormatLiquid
Product DescriptionDurvalumab Biosimilar, PD-L1 Monoclonal Antibody
IsotypeHuman IgG1
Regulatory StatusRUO
ClonalityRecombinant
ImmunogenHuman PD-L1
Species specificityHuman
Purity>95% by reducing SDS-PAGE
GradeIn vivo
Storage Conditions4ºC
Maximal Shelf Life12 months
SynonymsCD274, B7-H1
Target NamePD-L1, PDL1 CD274, B7-H1
Antibody TypeRecombinant
Research AreasActivated T cells, Activated B cells, Monocytes, Macrophages, Dendritic cells, NK cells, Immune Checkpoints, Cancer Immunology
See All FormatsClone Durvalumab

Background Information

Durvalumab is a fully human monoclonal antibody belonging to the immunoglobulin G1 kappa (IgG1κ) subclass, specifically engineered to target programmed death-ligand 1 (PD-L1). Structurally, Durvalumab is a glycoprotein with an approximate molecular weight of 149 kilodaltons (kDa). It is composed of two identical heavy chains and two identical light chains connected by interchain disulfide bonds, forming the Y-shaped quaternary structure typical of immunoglobulins. Each heavy chain contains one variable (VH) domain and three constant (CH1-CH3) domains, and each light chain contains a variable (VL) and constant (CL) domain. The antibody is produced in mammalian expression systems, such as Chinese Hamster Ovary (CHO) cells, which ensure correct folding, disulfide bond formation, and glycosylation consistent with human proteins.

The variable domains of Durvalumab contain complementarity-determining regions (CDRs) that confer high-affinity and selective binding to PD-L1. This interaction involves a combination of hydrogen bonds and hydrophobic contacts, allowing precise recognition of the ligand’s extracellular domain. Upon binding, Durvalumab inhibits the interaction between PD-L1 and its receptors, programmed death-1 (PD-1) and B7.1 (CD80). Blocking these ligand-receptor interactions prevents the inhibitory signaling pathway responsible for suppressing T-cell activation. In experimental systems, such blockade restores or maintains T-cell effector functions, illustrating the antibody’s role as a molecular modulator in immune checkpoint signaling studies.

Durvalumab’s Fc (fragment crystallizable) region retains the human IgG1 framework but is engineered to minimize immune effector mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). This is achieved through targeted amino acid substitutions that reduce binding affinity to Fc gamma receptors (FcγRs) and complement component C1q. The Fc domain also enables binding to neonatal Fc receptors (FcRn), extending the antibody’s half-life by promoting recycling and protecting it from lysosomal degradation. Overall, Durvalumab exemplifies precise monoclonal antibody design, with structural refinements that enhance target specificity, molecular stability, and functional control for mechanistic investigations of PD-L1-mediated immunoregulation.

Data Sheets

Anti-Human PD-L1 (Durvalumab Biosimilar) TDS

Related Protocols

Flow Cytometry Protocol

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Frequently Asked Questions

What are InnoCyto Biosimilar products?
InnoCyto biosimilars are research-grade recombinant antibodies or proteins engineered to closely replicate the sequence, structure, and target-binding activity of approved or well-characterized therapeutic antibodies (e.g., checkpoint inhibitors, anti-cytokine biologics). They are intended for research use to study the mechanism of action, efficacy, and combination potential of these therapeutic classes without the cost or access restrictions of clinical-grade material.
How similar are these biosimilars to the original therapeutic antibody?
Each biosimilar is produced using the published or inferred variable region sequence of the reference therapeutic and is expressed recombinantly to match the parent antibody's target specificity, isotype, and general binding profile. While designed for high functional similarity, InnoCyto biosimilars are for research use only and are not clinically validated equivalents of the approved drug product.
Are these antibodies suitable for in vivo studies?
Yes. InnoCyto biosimilars are manufactured with the same low-endotoxin, azide-free, carrier-free standards used across our in vivo product lines, making them suitable for animal efficacy, combination, and mechanism-of-action studies. Product pages indicate whether a given biosimilar is validated for in vivo use, in vitro use, or both.
What is the difference between a biosimilar and a recombinant "research antibody" targeting the same protein?
A biosimilar is specifically designed to mimic a known, named therapeutic antibody (matching its clinical target epitope and mechanism), whereas a general recombinant research antibody may target the same protein but bind a different epitope or lack the same functional properties. Biosimilars are the right choice when your study is benchmarking against, or modeling the action of, an approved or clinically studied biologic.
What quality and purity standards do biosimilar antibodies meet?
All biosimilars undergo the same rigorous QC pipeline as our other antibody lines: ≥95% purity by SDS-PAGE/SEC-HPLC, low-endotoxin testing via LAL assay, and binding/functional validation against the intended target. Certificates of Analysis (CoA) are provided per lot with full specifications.
Which therapeutic targets and mechanisms are covered in the Biosimilar line?
The line spans major immuno-oncology and immunology targets, including immune checkpoint pathways (e.g., PD-1/PD-L1, CTLA-4), cytokine and cytokine-receptor blockers, and other clinically relevant mechanisms. See each product page for the specific reference therapeutic and mechanism of action represented.

Have a product or application question? Consult our FAQs or contact us.